99% Estrogen Steroid Powder Estradiol For Anti-cancer
EMAIL: cgf at chembj dot com
Synonym: Beta-Estradiol-16, 17-D3
Appearance: white crystalline powder
Melting Point:178-179 °C
Boiling Point: 355.44°C
Standard: Enterprise standard
Usage: It may be used to treat certain types of prostate cancer (advanced androgen-dependent).
Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues. but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues. Estradiol is biosynthesized fromprogesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations. Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.
The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food and ethanol consumption were studied in ovarectomized rats given free access to food, a 10% ethanol solution, and water. EB led to an immediate, but transient, suppression of both food and ethanol intake. The time course and magnitude of these effects were virtually identical. While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethanol consumption apparently resulted from decreased rates of licking within bouts. Gradual increases in the frequency of eating and ethanol-drinking bouts allowed total food and ethanol intake to return to baseline within three weeks of the first injection. Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethanol intake were discussed in terms of ethanol's caloric property.
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