5-Aminolevulinic acid hydrochloride
Product Name:5-Aminolevulinic acid hydrochloride
Synonym:5-Aminolaevulinic Acid Hydrochloride;5-Aminolevulinic Acid HCL;5-Aminolevulinic Acid Hydrochloride;5-amino-4-ketovaleric acid hydrochloride;5-Amino-4-Oxopentanoic Acid HCL;5-Amino-4-Oxopentanoic Acid hydrochloride;ALA HCL;Alahydrochloride
Appearance: White Powder
Melting Point: ~150°C (dec.)
Flash Point: 155-157°C
Solubility: Soluble in dimethyl sulfoxide, methanol and water.
Usage: Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer).
What is 5-Aminolevulinic acid hydrochloride?
5-Aminolevulinic acid methyl ester hydrochloride is applied in variety of scientific fields with wide range. Examples of applications are shown below. Improvement of harvest yield or increase of plant greenness Supplement for culture of microorganism or cells from animals Research relating production of active oxygen derived from accumulation of excess amount of porphirins Photodynamic diagnosis for cancer research.
The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.
According to the presumed mechanism of action, photosensitization following application of aminolevulinic acid (ALA) topical solution occurs through the metabolic conversion of ALA to protoporphyrin IX (PpIX), which accumulates in the skin to which aminolevulinic acid has been applied. When exposed to light of appropriate wavelength and energy, the accumulated PpIX produces a photodynamic reaction, a cytotoxic process dependent upon the simultaneous presence of light and oxygen. The absorption of light results in an excited state of the porphyrin molecule, and subsequent spin transfer from PpIX to molecular oxygen generates singlet oxygen, which can further react to form superoxide and hydroxyl radicals. Photosensitization of actinic (solar) keratosis lesions using aminolevulinic acid, plus illumination with the BLU-UTM Blue Light Photodynamic Therapy Illuminator (BLU-U), is the basis for aminolevulinic acid photodynamic therapy (PDT).
1, Photodynamic diagnosis for cancer research.
2, Research relating production of active oxygen derived from accumulation of excess amount of porphirins.
3, Supplement for culture of microorganism or cells from animals
4, Improvement of harvest yield or increase of plant greenness 5-ALA is applied in variety of scientific fields with wide range.
5-Aminolevulinic acid hydrochloride used in cosmetic, PDT and fertilizer. Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic(photosensitizer).